I don't normally played with poly but wanted to try Gamma Glide / XP. Because of the poly I dropped the XP 3 lbs from (5%) normal and strung the Glide 10% lower than the XP in the mains. It was a little stiff at first but it only took a warm up to start liking it. If your going to full poly I would drop the tension at least 15% from what you normally play with. So if 52 is you normal try 44.