Yes, Sampras' first coach said something along the lines that Sampras would be able to win the biggest tournament if he had switched to a one-handed backhand. Not many Wimbledon champions with two-handed backhands existed up to then except, most notably, Borg and Connors.
Sampras' backhand was his biggest weapon before the switch to one-handed. He was a small kid. It certainly couldn't have hurt him on clay and very well may have shifted some of his fast-court wins over.