Pretty acknowledged that the Colts have the worst O line.
When you have bad pass protection, you don't run around in the pocket looking for 4th and 5th alternatives.
Part of the reason for the 49'ers success is that Smith gets rid of the ball ala Peyton.
When Smith tries to make something happens, he get's hit and fumbles, throw IT's, or misses by a mile.
You know, the classic 3 step drop and THROW THE BALL. Slants, outs, and fly's give the receivers a fair chance to catch a bad throw.