Good question and answer. I am poised to get the Bio 500.
I suspect its a case of adjusting the way you grip depending on the shot you play. Returning a heavy ball is bound to create the situation where a firmer grip is required, but otherwise I would try different ways of gripping to see what works. My only concern is going to a larger grip that works for some shots might not suit your all round game and overall grip comfort.
"Tennis is just chess with balls."
Prince Classic Graphite 100, Prince Exo3 Graphite 93...who knows...who cares.