To hit with open stance, it means you can reach the ball relatively easily. If you need to run through the shot in a running 2hbh, you need to be able to hit with closed stance, or slice it 1hbh.
Just like a forehand, a 2hbh is really a forehand with the other hand, and strong hand along for the ride and to provide some stability.
Nothing wrong with open stance 2hbh, but be aware your reach for a topspin shot is limited, but your ability to hit topspin sharp angled CC might be enhanced.
Obvoiously, you lose some backswing, but make up for that with more WW finish.