i am more sensitive to feeling a difference when a few grams is added to the hoop of a racket. my hands exceed a 4 5/8 grip size so i place two overgrips underneath a leather grip on a racket. i have found that leather grips expose the bevels better than the synthetic grips when wrapped over a few overgrips.
i can notice a differnce in a stock racket when after i wrap with the 3 total grips on my rackets.
i dont know the weight difference between most synthetic grips and leather grips...5 grams or so?? spread across a racket handle probably wouldnt offer much noticable difference as 5 grams at thh top of the hoop.