Due to blisters, I've recently replaced the leather grips of my new Wilson ncode 6.1 Tour 90 racquets to Dunlop hydramax (grip of my old Dunlop 300G) synthetic grips. The weight difference is minimal @ .2 oz, ie. from 12.5oz with the leather grip to 12.03oz with the sythetic grip. Consequently, the racquet balance is now around 9 pts HL from 12 pts with the leather grips.
I found the switch to improve my swings and more importantly, gave my hand comfort and improve my blisters.