We found a full bed of Cyclone great for this frame. This stems partly from the fact that our testers have long, fast strokes and tend to prefer the feel, control and spin they get from poly-based strings. A natural gut hybrid would work well for someone who wanted to balance the firm control of a poly with the feel, comfort and power of gut. It's hard to know what set-up would work for you without knowing your stoke style and feel-preferences. In general though, there is nothing about the specs of this racquet that make it incompatible with either a full bed poly or a hybrid.