Don't believe the commentary from people who don't use both. If you put string savers in your contact point nat gut will easily outlast syn gut by months. I get 2 weeks of daily hitting with a poly hybrid. 2 months with full synthetic if I'm lucky. And I cut the gut out after about 6 months with string savers when it lasts that long.
Without string savers all bets are off. I use mostly klip legend but occasionally vs babolat.
I've been supprised to find that on my wood frames JK Autograph and Wilson Advantage the strings don't last any longer for me despite the flexiness and tighter pattern.
I am not a big spin hitter so everything I just said should be regarded in that context.