I'd say Roddick's prime years were 2003 - 2009. During this time there, were 21 slams he had a chance at (leaving out the French Open). Other than his 2003 USO win, he lost to Federer in 7 of these, whilst losing to the likes of Gasquet, Johansson, Schuettler, Baghdatis, Muller, Kohlschreiber...