Yeah I'd have to disagree with that. He went 3-21 against Federer throughout his career....3-21...that has to be the most lopsided H2H in history among two players who are former slam winners and number ones, and none of those three wins even came at a slam or in the finals of a tournament.
Medvedev has already given both old Djokovic/Nadal and young Alcaraz/Sinner a much better run for their money than Roddick ever gave Federer. Medvedev has played Rafa in two 5-set slam finals, beaten Djokovic in a slam final while the Serb was going for CYGS, beat Sinner at Wimbledon, and Alcaraz at the US Open - that's more than Roddick has done vs any other ATG-tier player in his career, the closest he came was 2009 WI but he couldn't seal the deal. That was the only time in his career that he came close to beating an ATG level player late at a major, all the other times he either fell in 3 or 4 sets and the result never really looked in doubt