This will be the pair's 11th meeting, but their first off clay courts. Nadal leads the head-to-head 7-3, with his last win coming in the French Open final in June, while Thiem's last win was in Madrid, a 7-5, 6-3 victory for the Austrian.
Following victory over 2017 finalist Kevin Anderson, Thiem has reached his first ever quarter-final on hard courts in a Grand Slam, and this is the 18th time Nadal has been in the last eight at Melbourne or New York.
The defending champion Nadal has dropped two sets so far, one each to Karen Khachanov and Nikoloz Basilashvili in the third and fourth rounds respectively, while Thiem has dropped three - two to Steve Johnson in round 2 and one to Taylor Fritz in round 3.
Following victory over 2017 finalist Kevin Anderson, Thiem has reached his first ever quarter-final on hard courts in a Grand Slam, and this is the 18th time Nadal has been in the last eight at Melbourne or New York.
The defending champion Nadal has dropped two sets so far, one each to Karen Khachanov and Nikoloz Basilashvili in the third and fourth rounds respectively, while Thiem has dropped three - two to Steve Johnson in round 2 and one to Taylor Fritz in round 3.