I mostly agree but the H2H is 1-9, Musetti got him in 3 at Monte Carlo in 2023. So it can be done
I think in this case it’s less about one match and more about Djoko being the obstacle Musetti needs to clear in order to achieve his potential. Beating Sinner and Alcaraz isn’t it, those guys are who they are. Musetti will never be the favorite against them, but he should be the favorite against Djoko and winning these matches.
Remember Federer couldn’t become Fed until he figured out Nalbandian. This is similar to me, if Musetti figures Djoko out, then he’s safely the Third Man, the Murray to the Big 3.
But if he can’t get past the gatekeeper then he won’t even be meeting Alcaraz and Sinner. Zverev is also a gatekeeper to Musetti, but less so than Djoko