I would say only him and Murray have the ability to make big adaptations to depend on who their opponent is.
Murray sometimes goes too defensive but his good runs in IW and Miami last year and other periods where he has had good runs, he shows variety in his matches. Some matches he attacks the net alot, others he plays aggresive from the baseline and others he plays more defensive. The matches he loses are normally when he gets the tactics wrong and his opponent hits him off court ie. Tsonga at AO.
I made this point of Murray adapting his game about a year ago and another member on here said its like a chameleon - adapting to its surroundings, or in Murrays case, his opponent.
Federer is also capable of adapting and playing lots of different tactics. This is what makes him so successful and could also bring Murray success. With other players you know what they are going to bring to the table and therefore players can make a gameplan or come up with an idea to beat certain opponents. With Murray and Federer, they can play against all types of players and can read game situations well, therefore they can adapt their tactics during the match (this is where Murray has fallen short in his matches).