As I've posted ad nauseum, I'm a big synthetic gut fan. It was what I grew up on with wood rackets. I swapped over to natural gut in wood when I was 18. Liking/loving both, the thing about synthetic gut is it is cheap. It breaks when it's supposed to and it is arm friendly. That said, when a full bed of synthetic gut has a bit of age on it, the crosses move like crazy and stay out of place. I found that using a thin poly cross would remedy that. Natural gut on the other hand stays where it's supposed to. It is the ultimate performance string -- then and now. A large number of the world's top players still use natural gut in some from of hybrid. That should say volumes about its performance.
The thing is, all the posts in the world aren't going to really do it justice. Everyone should try natural gut at least twice. Buy two sets, put one in as a full bed. If you don't love it, try it as a hybrid -- the non-gut string in the crosses! I've seen teaching pros recommend poly to 50+ 3.0's. Those are the very players who would really benefit from natural gut. I've seen older ladies playing with Pure Drives and poly. I want to scream NOOOOOOOOOOOOOOOOOOOOOOOOOOO. Use the Pure Drive, sure, but string it with some 16 gauge natural gut.