Now and then I get pain in my wrist and thumb when I grip. Obviously hinders my tennis a bit and I am not sure what causes it. The pain starts on my wrist. If you traced a line around your hand, the pain starts 2 inches before the wrist and goes into the thumb joint as well. It can make it hard to hold a racquet until I get warmed up. It's really odd and I figure must be connected to an injured wrist. I have experienced it regardless of racquet and string selection. Anyone deal with this?