I would skip all of the rough and shaped crosses. All that will do is saw through your gut quicker. Instead, either use their round equivalents or just find a round string that plays very similar. If you really like a shaped string that doesn't have a round equivalent you can try it, but like I said, don't expect the gut to last as long. It already doesn't last that long for me, so I want to do whatever I can to keep it lasting as long as possible since it's playability will stick with it.
My all-time favorite hybrid setup is Luxilon Natural Gut/4G. The lux gut is a little less powerful than VS and a little more dampened of a feel. I'm not a fan of strings that feel too dampened (Head Hawk was a nightmare for me outside of the first 4 hours), but it being gut and also having 4G in the crosses it felt great. I played it right along side a VS/4G hybrid for my comparison.
Also, I would suggest stringing your gut tighter than the poly. They are completely different feeling string types and should be treated differently. If you do really like them being the same that's fine; there's nothing wrong with that. But don't string them the same just to have them the same tension. The vast majority of people who do gut/poly hybrids will drop at least 2 pounds, sometimes 10+ pounds going from the gut to the poly. I did mine at 54/50.
