Almost zero chance. First he has to get through Taylor, which won’t be easy. Then he has either Sinner, who he has a 1-4 record against. Or Medvedev, who he is 0-5 against. He needs a miracle.
Edit: my bad not Medvedev, Draper. Tiafoe has a 1-1 H2H against him. I have my doubts Draper can oust Sinner. Would be an interesting final to say the least if he does.