There was very little chance Djokovic loses that match if he comes in reasonably fresh. When you are tired out from playing multiple tough 4 setters and a really tough 5 setter, there's no way you can give it your best in the final. Zverev in particular destroyed his chances by taking him to 5 sets (Zverev after the match said he hoped Djokovic won the tournament - stupid comment to make after he destroyed his chances by tiring him out unnecessarily). You could see that Djokovic was physically gone at the start of the final. Medvedev almost certainly would not have beaten a physically fresh Djokovic.
Mark my words - if Djokovic and Medvedev meet at the AO and Djokovic is physically fresh, he beats Medvedev easily.