There are quite a few over the years; becoming more frequent as time goes on! The biggest obviously will always be Soderling knocking Nadal off at the '09 FO changing the course of history and the career of Federer! Without that bit of luck, courage and guile finally being displayed by an "also-ran" of the tour, Roger completed his CS and solidified his moniker of GOAT! Too many others have had chances, but never helped out Nole or Roger until '09 run of Robin! I keep saying Roger should do something quite nice for the Swede; a HOUSE would be fair! Nadal might have made up that lead of Roger's and surpassed him! Ya just never know! - Not trying to be a TROLL! Just happened to come across old VHS tape of Soderling taking Nadal out of that FO! In the poll, outside of Fognini and Kyrgios, the others who have upset Nadal have been anonymous, but Pouille should make a name for himself!