I've seen many people at my local gym increases their weight as they go through their sets. For example, if I start out at 200lbs, on isometric bench presses, for 15 reps, my second set would be 210lbs for 10 reps and my last set would be 220lbs for 5 reps. What if I were to reverse this by starting with heavier weights? For example, if I start out at 220lbs, on isometric bench presses, for 5 reps, my second set would be 210lbs for 10 reps and my last set would be 200lbs for 15 reps. Would this change anything? I was thinking that if I started out heavy then work my way downward, while increasing reps, would be a better work out. Reason? Doing 5 reps of 220lbs would be a lot harder on the third set than doing 5 reps of 220lbs at the beginning of the set. I would probably be able to do 7-8 reps of 220lbs if I started out with it, and therefore would end up lifting more net-weight. Of course, all this is assuming that my muscles are already warmed up. I would not start out with the heaviest weight I can handle otherwise.