Timothy outlined the reasons why slippery nylon strings don't work as well as polys. For those reasons I would stay away from multi crosses and focus on nylon and zyex monofilaments.
Here are some stiffness / inter-string friction numbers from TW University:
Gosen Powermaster II (rectangular nylon monofilament (syngut)): 179 / 0.08
Ashaway Zyex MonoGut 16 (100% Zyex monofilament): 118 / 0.088
Prince Recoil 16 (syngut core with PTFE (Teflon) wrap): 200 / 0.098
Gosen OG Sheep Micro 18 (syngut in a very flexible thin gauge): 178 / 0.114
The PTFE wrap of Recoil is harder and more durable than slippery coatings on strings like Bab N.Vy. I found it to perform quite similar to gut/copoly as a cross with gut mains. The inter-string friction of gut/Recoil is 0.079 and the stringbed stiffness about 145.
Gut with Gosen Micro 18 crosses works pretty well and is very comfortable. But it will notch and lock up after a while.
I would like to try Gosen Powermaster II, which is OG Micro in a rectangular cross section that is about 1 mm thick. Because of this shape, the angle of the weave is less, which should make it easier for the gut mains to slide and snap back. Also, because the string has no sharp edge or ridge (flat vs. circular), it might not cut into the gut and notch it as quickly. But I haven't tried this combo.
What I'm really interested in is gut mains paired with Ashaway 100% Zyex Monogut. You can see from the numbers that this string is very slippery (zyex is added to many copolymer strings to increases slickness) and less stiff than any nylon string on the market. It's also a monofilament, so there is no issue with strands getting torn up and roughening the surface like with multis (and with Ashaway's Dynamite Zyex strings, which have nylon outer braids that shred and lock the stringbed very quickly). This string relies on the inherent low-friction of the zyex material and not a coating for its slickness, so should remain slippery for the life of the string. But it may not have a hard enough surface to prevent the gut mains digging into the crosses and locking up the snapback mechanism. I haven't had time to try this but it's first on my list.
For comparison, here are the stiffness / inter-string friction numbers for some soft and slippery 3rd gen copolys (the softest copolys are the 18 gauge varieties, assuming they are strung at the same tension as a thicker gauge):
Isospeed Pulse 16: 193 / 0.07
Gosen Polylon Polybreak 18: 193 / 0.071
Gosen Polymaster II (also rectangular and 1mm thick): 207 / 0.074
MSV Co-Focus 16L: 213 / 0.089
Estimate for Co-Focus 18: 195 / 0.089
These five strings are only about 15% stiffer than Gosen Micro 18, which is a very flexible and comfortable syngut, so unless you have a super-tender arm, Timothy is probably right about gut/copoly being a better option than gut/slippery nylon.
And as a reference, gut / Alu Rough has inter-string friction of 0.088 but Alu Rough is much stiffer than the above thin 3rd gen copolys, with stiffness of 248. So a thin gauge soft copoly is only 15% stiffer than a thin gauge syngut, but Alu Rough is 25% stiffer than a thin 3rd gen copoly.
But the reason I think 100% Zyex Monogut might be so cool is that a gut/Zyex Monogut stringbed would have stiffness of about 110, while gut/thin copoly combos are around 145, and gut/Alu Rough about 170.
And if you find a good gut/poly alternative hybrid, please post a review in this thread:
http://tt.tennis-warehouse.com/showthread.php?t=356152
Stiffness / Inter-string friction data here:
http://twu.tennis-warehouse.com/learning_center/COFreporter.php