Useless information thread

Discussion in 'Odds & Ends' started by forzainter, Oct 17, 2007.

  1. stringertom

    stringertom Bionic Poster

    Joined:
    Sep 10, 2010
    Messages:
    50,037
    Location:
    On the lam from the sewretchian vortex
    Little Mac has some moxie but not enough weapons. Dimitrov morphed into Dimitrough to make that close this morning.
     
  2. Vcore89

    Vcore89 Legend

    Joined:
    Aug 27, 2012
    Messages:
    9,626
    Location:
    The Synapse SW1
    I thought he's gonna pull one like he did back in college against topseeded Mikael Torpegaard at the NCAA championship [but of course, this is the Big Boys Club!] and against Sam Groth at the Challenger level further back.
     
    stringertom likes this.
  3. Chadillac

    Chadillac Legend

    Joined:
    Jun 14, 2015
    Messages:
    6,839
    The infamous King Cobra isnt even a cobra
     
  4. Mike Bulgakov

    Mike Bulgakov Hall of Fame

    Joined:
    Aug 12, 2007
    Messages:
    3,698
    Location:
    The Future
    The infamous Olde English shares shelf space with King Cobra in S.F. Tenderloin liquor stores.
    [​IMG]
     
    Chadillac likes this.
  5. Rafa.the.Magnificent

    Rafa.the.Magnificent Professional

    Joined:
    May 4, 2017
    Messages:
    953
    Location:
    Lilburn, Georgia/USA
    It's pleasing to look at the Blue-Footed Booby![​IMG]
     
    ojo rojo and Mike Bulgakov like this.
  6. Mike Bulgakov

    Mike Bulgakov Hall of Fame

    Joined:
    Aug 12, 2007
    Messages:
    3,698
    Location:
    The Future
    For some reason, Will Ferrell's Swedish wife always looks like a mean person to me, bit she is probably very nice.
    [​IMG]
     
    Rafa.the.Magnificent likes this.
  7. ojo rojo

    ojo rojo Hall of Fame

    Joined:
    Jan 16, 2016
    Messages:
    2,444
    Location:
    could be worse
  8. Mike Bulgakov

    Mike Bulgakov Hall of Fame

    Joined:
    Aug 12, 2007
    Messages:
    3,698
    Location:
    The Future
    OCT 31, 2017 @ 10:08 AM
    The Origin Of Witches Riding Broomsticks: Drugs From Nature, Plus Shakespeare

    David Kroll , CONTRIBUTOR

    Today's timely post is an updated version of a story I wrote back in 2007 at my Terra Sigillata blog on ScienceBlogs.com, modified here at Forbes on Halloween in 2012, the first month I wrote in this space, then updated further with what I've learned since. But this story is one that I have been teaching in my pharmacology classes since 1992 at the University of Colorado School of Pharmacy and Pharmaceutical Sciences.

    Have you ever wondered, especially on Halloween, why witches are depicted as riding on brooms through the nighttime sky?

    The truth lies in science -- pharmacology, actually, and natural products pharmacology at that.

    Unfortunately, it's a story you may find difficult explaining to the kids.

    The excerpts I'm about to give you come from a superb and accessible pharmacology text from 1992 entitled, Murder, Magic, and Medicine, by John Mann, host of the BBC Radio 4 series by the same name.

    The historical depiction of witches riding broomsticks has its origins in hallucinogenic plant pharmacology, as popularized by Shakespeare, but the indigenous knowledge predates even him.

    Hallucinogenic chemicals called tropane alkaloids are made by a number of plants including Atropa belladonna (deadly nightshade), Hyoscyamus niger (henbane), Mandragora officinarum (mandrake) and Datura stramonium (jimsonweed). During the Middle Ages, parts of these plants were used to make "brews," "oyntments" or "witches' salves" for witchcraft, sorcery and other nefarious activities.

    Somewhere along the line, the observation was made that the hallucinogenic compounds, hyoscine in particular -- also known as scopolamine -- could be absorbed through sweat glands in the armpit or via the mucus membranes of the rectum or vaginal area. As compared to eating the plants or drinking their extracts, axial, rectal and vaginal routes of administration also bypassed the first cycle of rapid metabolism by the liver (and severe intestinal discomfort).

    Broomsticks

    Just how did the alleged witches apply said ointments? According to Mann, the earliest clue comes from a 1324 investigation of the case of Lady Alice Kyteler:

    "In rifleing the closet of the ladie, they found a pipe of oyntment, wherewith she greased a staffe, upon which she ambled and galloped through thick and thin."

    And from the fifteenth-century records of Jordanes de Bergamo:

    "But the vulgar believe, and the witches confess, that on certain days or nights they anoint a staff and ride on it to the appointed place or anoint themselves under the arms and in other hairy places."

    These passages account for why so many of the pictures of the time depict partially clothed or naked witches "astride their broomsticks," as shown in the woodcut image featured here.

    Shown in Mann's book with the caption, "A seventeenth-century engraving of a witch being prepared for the Sabbat. Note the administration of the salve." Credit: Wellcome Institute Library, London
    Why Flying?

    But what about the issue of flying on said broomsticks?

    The tropane alkaloid hallucinogens tended to cause sleep, but with dreams that involved flying, "wild rides" and "frenzied dancing." A 1966 description of tropane alkaloid intoxication was offered by the Gustav Schenk:

    "My teeth were clenched, and a dizzied rage took possession of me...but I also know that I was permeated by a peculiar sense of well-being connected with the crazy sensation that my feet were growing lighter, expanding and breaking loose from my own body. Each part of my body seemed to be going off on its own, and I was seized with the fear that I was falling apart. At the same time I experienced an intoxicating sensation of flying...I soared where my hallucinations - the clouds, the lowering sky, herds of beasts, falling leaves...billowing streamers of steam and rivers of molten metal - were swirling along."

    So, these psychosensory experiences of flying were associated with boiled up hallucinogenic plants applied to the vulvovaginal area with a broomstick, probably used to mix the concoction.

    An aside: Legendary pharmacologist, Susan Band Horwitz, PhD, reminded me a few years ago that the same passage from Macbeth quoted above also contains a reference to the source of one of our most useful natural product anticancer drugs, paclitaxel (Taxol).

    In 1979, Dr. Horwitz and her then-doctoral student, Peter Schiff, and Jane Fant, published in Nature the seminal report demonstrating that taxol acts by promoting microtubule polymerization to the point that tumor cells cannot coordinate chromosomal segregation.

    It works this way in everyone, not just witches.

    I was honored to work from 2002 to 2008 with the two gents who isolated Taxol from the Pacific yew and showed its anticancer activity, the late Monroe Wall, PhD, and Mansukh Wani, PhD.

    I never cease to be amazed or impressed by how much of our folk history is influenced by drugs from nature -- natural products -- used in cultural or medical rituals. The fact that plants and other organisms make chemicals that affect human biology triggered my own interests in this field. Over nearly 30 years of working in pharmacology and toxicology, I spent the bulk of my time working with chemists far more talented than I trying to discern if the natural world held more anticancer drugs for us.
    https://www.forbes.com/sites/davidk...gs-from-nature-plus-shakespeare/#1f899ec961a9
    [​IMG]
     
  9. ojo rojo

    ojo rojo Hall of Fame

    Joined:
    Jan 16, 2016
    Messages:
    2,444
    Location:
    could be worse
    Shakespeare, shrooms and shamans. What a combo! Love it. Thanks for sharing


    [​IMG]
    [​IMG]
     
  10. Mike Bulgakov

    Mike Bulgakov Hall of Fame

    Joined:
    Aug 12, 2007
    Messages:
    3,698
    Location:
    The Future
  11. Rafa.the.Magnificent

    Rafa.the.Magnificent Professional

    Joined:
    May 4, 2017
    Messages:
    953
    Location:
    Lilburn, Georgia/USA
    I thought so too! Was a very interesting read!
     
    Mike Bulgakov and ojo rojo like this.
  12. ojo rojo

    ojo rojo Hall of Fame

    Joined:
    Jan 16, 2016
    Messages:
    2,444
    Location:
    could be worse
    In before Tawm mentions a pachydermal parallel in pink... and green
     
  13. stringertom

    stringertom Bionic Poster

    Joined:
    Sep 10, 2010
    Messages:
    50,037
    Location:
    On the lam from the sewretchian vortex
    Walt Disney was so far ahead of his time!

     
  14. jaggy

    jaggy Talk Tennis Guru

    Joined:
    Jun 8, 2006
    Messages:
    20,988
    Location:
    Chapel Hill, NC
    Although a Las Vegas showgirl may be as 'short' as 5'8 most are at least 5'10.
     
  15. Vcore89

    Vcore89 Legend

    Joined:
    Aug 27, 2012
    Messages:
    9,626
    Location:
    The Synapse SW1
    At 1.81m or [5'11] I'd be too short to be a show guy. Those guys must belong in the Tall Club, 1.88m and up.
     
  16. stringertom

    stringertom Bionic Poster

    Joined:
    Sep 10, 2010
    Messages:
    50,037
    Location:
    On the lam from the sewretchian vortex
    Gene Kelly, @Sentinel 's favorite dancer, was 5'7".
     
    Sentinel and Vcore89 like this.
  17. ojo rojo

    ojo rojo Hall of Fame

    Joined:
    Jan 16, 2016
    Messages:
    2,444
    Location:
    could be worse
    Same dimensions as the circumference of a certain man in pink and green
     
    Sentinel, Vcore89 and stringertom like this.
  18. stringertom

    stringertom Bionic Poster

    Joined:
    Sep 10, 2010
    Messages:
    50,037
    Location:
    On the lam from the sewretchian vortex
    :p And :D man on a diet, maybe.
     
    Vcore89 and ojo rojo like this.
  19. Vcore89

    Vcore89 Legend

    Joined:
    Aug 27, 2012
    Messages:
    9,626
    Location:
    The Synapse SW1
    Today in History, 19th January 1809, poet, author and literary critic Edgar Allan Poe is born in Boston, Massachusetts.

    On this day in 1966, Indira Gandhi becomes the first female Prime Minister; the daughter of the first Indian Prime Minister, Jawaharlal Nehru.
     
    Mike Bulgakov likes this.
  20. jaggy

    jaggy Talk Tennis Guru

    Joined:
    Jun 8, 2006
    Messages:
    20,988
    Location:
    Chapel Hill, NC
  21. stringertom

    stringertom Bionic Poster

    Joined:
    Sep 10, 2010
    Messages:
    50,037
    Location:
    On the lam from the sewretchian vortex
    Just passed 50K...still Bionic.
     
    Mainad and Mike Bulgakov like this.
  22. FedFosterWallace

    FedFosterWallace G.O.A.T.

    Joined:
    Dec 28, 2015
    Messages:
    11,136
    Location:
    US
    Bolded: Disappointingly, seems to be the case. Absolutely loved this game when it seemed as if someone had hit upon a simple puzzle that relied purely on logic and reason, independent of math. Really off-putting when I came across these stumpers that are impregnable fortresses... until you insert the mathematical key, that is.
     
  23. Sentinel

    Sentinel Bionic Poster

    Joined:
    Jan 21, 2008
    Messages:
    49,501
    Location:
    Telly, watching AO.
    Nonsense. My favorite private dancer is Poobs on court doing his split step thing. Gene is a distant second.

    "split steppin in the rain .."

    oh wow ! Congrats !!!
     
    stringertom likes this.
  24. Vcore89

    Vcore89 Legend

    Joined:
    Aug 27, 2012
    Messages:
    9,626
    Location:
    The Synapse SW1
    Perhaps request for ''SuperNatural'' [Smootherer] designation?
     
    stringertom likes this.
  25. Mainad

    Mainad Bionic Poster

    Joined:
    Apr 1, 2011
    Messages:
    30,574
    Location:
    Manchester, UK.
    Obviously they've run out of categories to describe you. Personally, I think you should be designated "SuperHero"! :)
     
    stringertom likes this.

Share This Page