What is your opinion about aging?

[Raul_SJ]

It's cyclical. Booms & busts come and go. In the meantime, sock whatever you can away.

Economies and wages recovered in the past. The difference this time is a globalized economy. The economy may recover but this time the wages may never recover.
Hence the plight of millennials that are not able to afford homes...Sureshian economics says they should not be given raises and be content not to be replaced by robots.

For all of you who think your work is important, if you truly reflect on it, you will realize it is mostly work that can be automated or done cheaper by somebody else. So basically, you really don't deserve the money you make. You are just a placeholder for the time till which you can be replaced.

Think about it.

 

[sredna42]

I think the shark is just smiling.

I love these shark memes, peurile I know but man they always make me laugh

Hard to believe that sharks can remain cancer-free for 500 years, especially given all the pollutants in the ocean.

Last time I read about it was 20 years ago, and it seemed to be understood that they didn't get it. Oh well, sue me. My lawyer's name is Dr.Gonzo, let him know when you want to start proceedings.

To be fair though, maybe it is rarely found as the ones that do get it simply die quickly, unlike humans where we prolong our survival through technology.

They'll eventually understand the hormonal events that trigger death, or understand what genes instruct our bodies to self destruct. There was alot of talk about the length, or lack thereof, of telomere caps, being responsible for ageing, once they degraded. While probably correct in part, I feel that death is hard wired into us anyway. The pattern is clear to see across most other species on the planet, the extremely long lived species show that genes can allow an organism to live for along time, if not forever.

LOL the ironic thing is, is that life extension may take leaps and strides from studying cancer cells, which are immortal also.

You gotta laugh, what else can you do

 

[kramer woodie]

Holy Cow. I had no idea Greenland sharks live for 500 years.
If there's a God he must really really like sharks and hate humans.

Raul_SJ

Did you ever consider that God created humans to keep sharks full, healthy, and strong? I can just see a shark thinking; human, soft and
chewy, good protein less fat.

Aloha

 

[kramer woodie]

Sharks don't get cancer either.
The Great White God of Death. Dat mouth a direct portal to the other side LOL

If were were immortal, the planet would be overflowing with deathless humans in a geological blink of the eye, we would exhaust all resources, and the species would die. Also if we were immortal, we would not be able to evolve or adapt to our environment as it changed across the millenia, either individually (duh) or through natural selection, we would not be plastic, and so eventually/inevitably the species would become extinct.

We are just survival machines for our genes. We age because as far as Mother Nature is concerned, we have (or should have by now) fulfilled our one job, to reproduce, have had time enough to raise our progeny, and thus there is no further point to our continued existence. So we begin to fall apart. LOL just like a bell curve, reproduction is the mean.

So does ageing suck? Of course it does. It is basically dying whilst still alive.

You worry about this, and other, chit too much though, and life passes you by. You just **** years away. Just play tennis.

sredna42

Old Star Trek episode. Captain Kirk beams don't to a planet. Stuck in an area crammed with people, they can't turn around, nor lie down.
Kirk rescued by kings daughter, she comes on to him, but get sick. She is happy because her planet had overcome disease and death.
Therefore, her role was to get sick and spread that sickness amongst her people so that there would be room for future generations.

Aloha

 

[Raul_SJ]

@kramer woodie The earth can still support a few more humans ... and when it eventually cannot, there are billions of uninhabited planets.

 

[movdqa]

Why would that be? The recession in 2001 (a generation ago) was really bad. Today's employment numbers are some of the best ever.
This young generation seem to have it relatively good compared to the previous one.

The recession in 2001 wasn't really bad. It mainly affected the tech sector. It did have an outsized effect on the tech sector because that was in a huge bubble. The Great Recession of 2008-2009 had a much bigger effect on the general economy.

 

[movdqa]

I love these shark memes, peurile I know but man they always make me laugh

Last time I read about it was 20 years ago, and it seemed to be understood that they didn't get it. Oh well, sue me. My lawyer's name is Dr.Gonzo, let him know when you want to start proceedings.

To be fair though, maybe it is rarely found as the ones that do get it simply die quickly, unlike humans where we prolong our survival through technology.

They'll eventually understand the hormonal events that trigger death, or understand what genes instruct our bodies to self destruct. There was alot of talk about the length, or lack thereof, of telomere caps, being responsible for ageing, once they degraded. While probably correct in part, I feel that death is hard wired into us anyway. The pattern is clear to see across most other species on the planet, the extremely long lived species show that genes can allow an organism to live for along time, if not forever.

LOL the ironic thing is, is that life extension may take leaps and strides from studying cancer cells, which are immortal also.

You gotta laugh, what else can you do

I think that people have cancer cells all the time - more as you get older as genetic mutation errors go up exponentially with time. The body has various repair mechanisms, though, for mutations and these clean up those cancer cells. Of course if there are problems with the immune system, such as the DNA Mismatch Repair system being missing from a person or the immune system is weakened for some reason; then mutated cells might not be cleared and develop into a tumor which the body doesn't have the ability to clear.

The latest technologies show a lot of promise. The National Cancer Institute has developed a therapy where they take some of your white blood cells, modify them to kill your tumor cells (if necessary), multiply them by 1x10^11 and put them back into your body to kill your tumors. This is different from traditional chemotherapy which attacks most of your cells to kill, shrink or stabilize the tumor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5178827/pdf/nihms836415.pdf

This patient's case (I've chatted with her and her husband) was one of the first ones and she had the required Allele that expresses KRAS G12D on the cell surface. There are many kinds of cancer that are inside the cell so you can't make a drug that attacks it as the drug won't know which cells have a problem. The required Alleles bring the mutation to the cell surface where white blood cells can target it. The Alleles required are uncommon outside of one where about 1/3rd of Asians may have it and the idea is to find a way so that the Alleles aren't required for the therapy. This therapy is expected to cost over $1 million but I think that costs will come down rapidly with scale. This therapy only addresses two, specific mutations. There are hundreds of kinds of mutations and it will take some time to develop therapies for each kind. As you might expect, the most common or otherwise uncurable mutations will be worked on first.

KRAS G12D is the most common mutation in Pancreatic cancer which has a horrible survival rate. It's also the most common for CRC. The trials are only available for Stage 4 patients as they're the folks that need it the most.

 

[movdqa]

@kramer woodie The earth can still support a few more humans ... and when it eventually cannot, there are billions of uninhabited planets.

My state is mostly empty. There are lots of other states like that too.

 

[maximus]

It's natural. We must have a goal to reach at least every 5 years. Achieving those goals will keep us alive and should leave us preoccupied; hence, nothing to be afraid of. We must take care of our body while we're young and watch what we eat so we can still enjoy the food we want when we grow old. We must stay away from vices and unhealthy habits to keep a healthy mind, body and soul. And best of all, we should keep playing tennis as we age!

 

[Soul]

In the past much has been written about fasting and calorie restriction to extend life and slow down aging. Was watching a video the other day of Professor Thomas Seyfried and his research into fasting and the ketogenic diet to manage and fight cancer. According to him appears the dietary approach is having some success with humans. Thought if true, could explain why some have found fasting helpful.

 

[MathGeek]

My observations suggest that most of the decline of aging relates to the tendency of well fed Americans to keep eating about the same even though activity levels and metabolism slows. Folks who can keep the food intake balanced with the calories burned tend to have much higher quality of life in their 50s and beyond. Aging seems to be a much different experience for folks without all the weight gain.

 

[movdqa]

My observations suggest that most of the decline of aging relates to the tendency of well fed Americans to keep eating about the same even though activity levels and metabolism slows. Folks who can keep the food intake balanced with the calories burned tend to have much higher quality of life in their 50s and beyond. Aging seems to be a much different experience for folks without all the weight gain.

We see a lot of that because it is so common. But I run into fit people (some ultrafit) that come down with cancer, GI problems, autoimmune disorders, etc. Some of these have genetic bases. Excess weight causes a lot of problems. Everytime I go to the doctor, I'm asked about smoking, what medications I'm on (none), how much activity I do a week (I do more in a day than most people in a week), etc. The country as a whole in our age range is in sad shape.

 

[Raul_SJ]

My observations suggest that most of the decline of aging relates to the tendency of well fed Americans to keep eating about the same even though activity levels and metabolism slows. Folks who can keep the food intake balanced with the calories burned tend to have much higher quality of life in their 50s and beyond. Aging seems to be a much different experience for folks without all the weight gain.

If one is maintaining a normal weight with a certain caloric intake and activity level, and then metabolism slows, how is it possible to reduce caloric intake without feeling hungry and tired?

 

[movdqa]

If one is maintaining a normal weight with a certain caloric intake and activity level, and then metabolism slows, how is it possible to reduce caloric intake without feeling hungry and tired?

Bulk food.

 

[Goof]

Aging is great for barrel aged and sour beers and certain high ABV styles (e.g. RIS, a strong barleywine), but not for others.

 

[sureshs]

Aging is great for barrel aged and sour beers and certain high ABV styles (e.g. RIS, a strong barleywine), but not for others.

What about cheese?

 

[LGQ7]

 

[ByeByePoly]

 

[kramer woodie]

@kramer woodie The earth can still support a few more humans ... and when it eventually cannot, there are billions of uninhabited planets.

Raul_SJ

Another older movie, popular with younger generations, was The Matrix. I found the comment by the bad guy to be spot on. If I remember
correctly the bad guy said, " humans are like a virus that eventually kills of the host". While having been on the planet since the 40s, I can
attest to the bad guys comment being correct, as I see human viruses mutate and demand a free ride, screaming it's not fair, leaving their
poop for others to clean up, as they shoot up and drop out leaving their needles behind for someone to stumble on and become infected
with HIV.

The US is in sad shape, 50 percent fat for one thing, but the main viral mutation is the lack of education for self responsibility. This mutation will get worse before it gets better, (if it every gets better). It is always someone else's fault, it's not fair, why should I have to
listen to this, I am entitled because I am breathing, etc..

One thing is certain, viruses mutate and Never for the Better.

Aloha

 

[Keendog]

I hate getting older but it's better than the alternative.

Just buy yourself a Mustang and get on with it

 

[el sergento]

 

[maleyoyo]

A baby and an older person go through the same reversal aging process ( growth vs decay).
Growing hair, teeth...losing hair, teeth
Getting taller...getting shorter
Eat more...eat less
The bad news is the decay process starts between 25-30 yrs old for most.
The good news is we can have some control of the aging process
The ugly news is it doesn't take long to make a negative impact yet a long time to have a positive one.

 

[Crocodile]

My view about ageing is that if we have a choice in how we can live well we should implement it.
Sure having the right genes and life circumstance can make a difference but there is so much more we can do to make an impact.
Some of the research coming out from the "Blue Zones Living" and "Longevity Project", are helping to highlight what long living people can do.
Too much of all our societies these days is not geared towards healthy aging and it is dissapointing to see so many people suffer from conditions that could have been avoided if both as individuals and communities we could live the good life. We seem to have made living a difficult task.
It is time to get on board and make things happen in all facets of life.

 

[esantoro]

I turned 50 today and am looking forward to playing in the 50+ Seniors tournaments. I feel that in my 20s and 30s I never really played within myself and always tried to hit every ball as hard as I could, enjoying the view as the ball whizzed a foot over the net....to the middle of the court where some 50-year-old pusher simply knocked it back to me using 90% of the energy I had expended, and where I promptly committed an unforced error.

Now I am ready to play within my capabilities and focus on technique, angles, and depth, because as SasF, I am no longer going to run all over the court chasing balls. I will make the 20-year-olds and 30-year-olds do that.

There is always a silver lining.

 

[Mac33]

I I have been unable to lose my tiny gut and I am still 70-71 kg.


For the next few weeks I am going to eat mostly fruit.

I found this video very insightful.

 

[movdqa]

I spoke to one of our previous fitness center managers about those folks that lose a ton of weight and then develop a six-pack. I asked how they can do that given the overhang of loose skin. She told me that they had surgery to get rid of the excess skin.

 

[kramer woodie]

I spoke to one of our previous fitness center managers about those folks that lose a ton of weight and then develop a six-pack. I asked how they can do that given the overhang of loose skin. She told me that they had surgery to get rid of the excess skin.

Hi, movdqa

You got told the truth! Same thing happens to those who have a gastric by pass or those women who have the fat sucked out of their
saddle bags. You do not want to see all that stretched out extra skin, only view after skin has been tightened.

Aloha

 

[Stretchy Man]

There's some nice things about being middle-aged. You get much better at judging people, having money after finally paying off the mortgage is really nice, and lot's of free time after the kids grow up.

But the realization that I'm going to die one day, possibly tomorrow, is not cool.

 

[movdqa]

There's some nice things about being middle-aged. You get much better at judging people, having money after finally paying off the mortgage is really nice, and lot's of free time after the kids grow up.

But the realization that I'm going to die one day, possibly tomorrow, is not cool.

It can get a lot closer than that. I've been running into more of that with family, friends and co-workers.

 

[kramer woodie]

There's some nice things about being middle-aged. You get much better at judging people, having money after finally paying off the mortgage is really nice, and lot's of free time after the kids grow up.

But the realization that I'm going to die one day, possibly tomorrow, is not cool.

Stretchy Man

You got that Right! Famous last words of a dying man, "But, but, I am not ready yet"!!!! Only if he was feeling good the day before, if in
very bad health with low quality of life and mentally beat down then, "It's about time! Why did I have to suffer so long? Just get it over
with"!!!

We, most all of us, are definitely to much in love with, "Pride of Our Flesh"!!!

Aloha