Tsitsipas is least at this point. He is never going to go deep in Wimbledon and USO. Too many players can stop him in RG now, he let his chance go in 2021... His best chance is the AO but only if he plays his best and faces someone like Rublev or Ruud in the final... Unlikely but not impossible.
Rublev can't even win a QF but who knows... Maybe if he finally wins 1, it'll give him extra confidence... He is more complete and mentally stronger than Tsitsipas so I give him better chances.
Sinner Zverev and Rune peak higher and seem complete (more complete than Medvedev, who can only win on HC). Once Djokovic is gone, they'll have chances to win 1. Alcaraz isn't gonna win everything. Sinner and Zverev both beat him in a Slam, they will do it again. Rune is in poor form now but he'll bounce back next year.