Okay since you are hopefully being serious.
Laver faced some players of the level of Roddick on serve (and I think Roddick has an all time great serve) like Pancho Gonzalez, Lew Hoad, Roscoe Tanner, Arthur Ashe, Stan Smith and John Newcombe so I think he could be somewhat effective returning serve against Roddick. Since Roddick's serve is so great I would generally expect in most matches that Roddick to win the clear majority of points (amd that would be the case against any player that lived I believe except maybe on slow clay at times) that he serves but I believe Laver would break Roddick more often than Roddick would break him.
It's a tough question since Roddick is a fabulous serve but I do believe Laver would be far more effective than an average player in returning Roddick's serve. If Laver was "on" his game, it would be very interesting to see what he would do.
Roddick has arguably the best serve of the 2000's. Roddick has in my opinion less skills than for example Federer but he holds serve more often.
With Vince it's easy. Roddick wins zero points on serve against the almighty Vince.