Lew II
G.O.A.T.
Since Big3 are often said to be too young or too old in some h2h, let's see only the h2h when they were old enough to be 1, 2, 3 times Slam champions or young enough to be yet to win 1, 2, 3 more Slams.
Between their first and last Slam title
Djokovic-Nadal (AO08-WI19) overall 26-20, in Slams 6-6
Djokovic-Federer (AO08-AO18) overall 22-17, in Slams 9-4
Nadal-Federer (RG05-AO18) overall 22-14, in Slams 9-3
Between their first and last 2 Slam titles
Djokovic-Nadal (AO11-AO19) overall 21-9, in Slams 6-4
Djokovic-Federer (AO11-WI17) overall 17-9, in Slams 7-2
Nadal-Federer (RG06-WI17) overall 18-13, in Slams 8-3
Between their first and last 3 Slam titles
Djokovic-Nadal (WI11-RG18) overall 17-9, in Slams 4-4
Djokovic-Federer (WI11-AO17) overall 14-8, in Slams 7-1
Nadal-Federer (RG07-AO17) overall 16-8, in Slams 7-2
Between their first and last Slam title
Djokovic-Nadal (AO08-WI19) overall 26-20, in Slams 6-6
Djokovic-Federer (AO08-AO18) overall 22-17, in Slams 9-4
Nadal-Federer (RG05-AO18) overall 22-14, in Slams 9-3
Between their first and last 2 Slam titles
Djokovic-Nadal (AO11-AO19) overall 21-9, in Slams 6-4
Djokovic-Federer (AO11-WI17) overall 17-9, in Slams 7-2
Nadal-Federer (RG06-WI17) overall 18-13, in Slams 8-3
Between their first and last 3 Slam titles
Djokovic-Nadal (WI11-RG18) overall 17-9, in Slams 4-4
Djokovic-Federer (WI11-AO17) overall 14-8, in Slams 7-1
Nadal-Federer (RG07-AO17) overall 16-8, in Slams 7-2