I thought about this, and I wondered "these low-ranked players, are they lucky? Are we overestimating them?". I'm now certain that some people here would say something like "no, these low-ranked players could never have defeated Laver and Rosewall".
So I checked. Are these guys lucky or not? As you know, there have been 333 classical majors with seeds, since 1925. In 32 cases these majors were won by a player who wasn't one of the first 8 seeds (11 times he was unseeded), so I counted how many of them he had to defeat before winning the tournament.
The results are interesting, so I post them all.
RG 1928 Henri Cochet (15) d. Hunter (2), Boyd (7), Lacoste(1)
US 1930 John Doeg (11) d. Lee(4), Tilden (1)
RG 1939 Don McNeill (u) d. Puncec (2), Riggs (1)
US 1943 Joseph Reuben Hunt (u) d. Parker (1), Talbert (4), Kramer (3)
RG 1946 Marcel Bernard (13) d. Segura(4), Petra (1), Drobny (3)
US 1948 Pancho Gonzales (15) d. Parker(1), Drobny (4)
US 1950 Arthur Larsen (11) d. Drobny(4), Brown (7), Flam (3)
WB 1954 Jaroslav Drobny (11) d. Hoad (2), Patty (7), Rosewall (3)
US 1957 Mal Anderson (u) d. Savitt(2), Davidson(3), Cooper (1)
US 1966 Fred Stolle (u) d. Ralston (3), Graebner (7), Emerson (2)
US 1973 John Newcombe (10) d. Rosewall (5), Kodes (6)
AO 1976 Mark Edmondson (u) d. Dent(5), Rosewall (1), Newcombe (2)
RG 1982 Mats Wilander (u) d. Lendl (2), Gerulaitis (5), Clerc (4), Vilas (3)
WB 1985 Boris Becker (u) d. Nystrom (7), Jarryd (5), Curren (8)
WB 1987 Pat Cash (11) d. Wilander (3), Connors (7), Lendl (2)
RG 1989 Michael Chang (15) d. Lendl (1), Edberg (3)
US 1990 Pete Sampras (12) d. Muster (6), Lendl (3), Agassi (4)
RG 1991 Jim Courier (9) d. Edberg (1), Agassi (4)
WB 1992 Andre Agassi (12) d. Becker (4), Ivanisevic (8)
RG 1993 Sergi Bruguera (10) d. Sampras (1), Courier (2)
US 1994 Andre Agassi (u) d. Chang (6), Stich (4)
WB 1996 Richard Krajicek (17) d. Sampras (1)
US 1997 Gustavo Kuerten (u) d. Muster (5), Kafelnikov (3)
US 1997 Patrick Rafter (13) d. Chang (2)
RG 1998 Carlos Moya (12) d. Rios (3)
AO 1999 Yevgeny Kafelnikov (10)
RG 1999 Andre Agassi (13) d. Moya (4)
WB 2001 Goran Ivanisevic (u) d. Safin (4), Henman (6), Rafter (3)
AO 2002 Thomas Johansson (16)
RG 2002 Albert Costa (20) d. Kuerten (7)
US 2002 Pete Sampras (17) d. Haas (3), Agassi (6)
RG 2004 Gaston Gaudio (u) d. Nalbandian (8), Coria (3)
As you see, only twice (Kafelnikov and Johansson) the player has been very lucky. Kafelnikov did not meet any seed at all! Since 1996 other players have been lucky: Krajicek, Rafter, Moya, Agassi and Costa. This is correlated to the increase of early losses in '90 and '00, likely due to the new seeding system, as Urban pointed to.
By the way, 32 cases are about one out of 10, and we're discussing a 20 majors-streak. And in these 32 cases the winner wasn't even in the first 8 seeds: that's not even Emerson, that's Osuna or McKinley, Stolle at best!
Of course, some times the winners were "oldies but goldies" (Newcombe, Sampras in 2002) or just erratic (Agassi). But that does not mean their victory was taken for granted, as we all remember.
And many times these players not only weren't lucky, but had to defeat three high seeds. Wilander, in 1982, defeated four, and these four were all very strong on clay. Among the players defeated there are Lacoste, Tilden, Kramer, Hoad, Rosewall, Lendl, Sampras, all potential GOATs: each one of them defeated on his best surface. Drobny's victory in Wimbledon, 1954, was particularly impressive: he defeated both Hoad and Rosewall!
Only strange thing: between 1957 and 1973 there has been just one of such cases. Maybe this will please Bobbyone.