Usually fish oil comes in 3 different grades. The regular stuff, molecular distilled, and pharmaceutical grade. The latter two is desirable because, then, you know you have none of the vitamin A, mercury and other pollutants in the stuff. And you can be reasonably sure the stuff hasn't oxidized yet. The cost increase from regular to molecular distilled isn't that high. From molecular distilled to pharma grade, there you see the jump.
You can pretty much tell the difference between the molecular distilled and pharma grade by the EPA/DHA levels per gram. Regardless of what brand or company you buy, the quantities work about the same. I've found that I can't even take the molecular distilled without significant gastric distress.
My athletes would often recognize each other when sitting around a table because those I'd be training would break out the fish oil during the meal. That's how I got the nickname "the fish oil guy" among athletes. But that's also how I get people so lean so fast.
Anyone who wants to put on muscle and lose fat should be on 30-45 grams of fish oil per day. That's just three tablespoons of fish oil. It would be a pain in the ass with capsules though because that's around 45 capsules per day, but it's easy with a straight oil.
what would the O3 have to do with weight loss. I can see the benefits everywhere else but this i dont understandand.
It enhances fat metabolism.
-Robert
Yes.
Omega-3 fatty acids are anti lipogenic (they block fat storage), anti catabolic, anti inflammatory, and they increase beta-oxidation (fat burning), improve insulin sensitivity, increase thermogenesis and have a whole lot more positive effects on fat loss that I don't have the time or need, to cover in this post.
Omega-3 control gene transcription. Omega-3 play essential roles in the maintenance of energy balance and function as fuel partitioners in that they direct glucose toward glycogen storage, and direct fatty acids away from triglyceride synthesis and assimilation and toward fatty acid oxidation.
Omega-3 appear to have a unique ability to enhance thermogenesis and thereby reduce the efficiency of body fat deposition.
Omega-3 exert their effects on lipid metabolism and thermogenesis by up-regulating the transcription of the mitochondrial uncoupling protein-3 (UCP3), and inducing genes encoding proteins involved in fatty acid oxidation (e.g. carnitine palmitoyltransferase and acyl-CoA oxidase) while simultaneously down-regulating the transcription of genes encoding proteins involved in lipid synthesis (e.g. fatty acid synthase).
Omega-3 "control" "enhance" "up-regulate" and "down-regulate." My familiarity with physiology and medicine tells me a fatty acid does none of those things independently but may mediate control from another locus. These oversimplifications are drivel. Also, how can something be "anti catabolic" (catabolism is the breakdown of complex biologic compounds into simpler compounds) at the same time that they increase "fat burning" and reduce "body fat deposition (which would be anti-anabolic)?
Omega-3 "control" "enhance" "up-regulate" and "down-regulate." My familiarity with physiology and medicine tells me a fatty acid does none of those things independently but may mediate control from another locus. These oversimplifications are drivel. Also, how can something be "anti catabolic" (catabolism is the breakdown of complex biologic compounds into simpler compounds) at the same time that they increase "fat burning" and reduce "body fat deposition (which would be anti-anabolic)?
A certain fish oil from cold water fish, omega-3, is correlated with a decrease of cardiovascular diseases. It thins the blood, thus heart attacks, etc. are less likely. If I remember correctly, the correlation was first noticed in Denmark. I'm not sure if there is absolute proof for this, but there is enough circumstantial evidence to suggest that Omega-3 is in fact beneficial.
It's true that many fish itself may contain an elevated amount of mercury, a toxin, because companies dump crap into our water. So eating salmon everyday MAY increase risks.
El Diablo, I believe that in this particular instance, the term "anti-catabolic" refers to fish-oil's alleged ability to stop/reduce the breakdown of muscle tissueOmega-3 "control" "enhance" "up-regulate" and "down-regulate." My familiarity with physiology and medicine tells me a fatty acid does none of those things independently but may mediate control from another locus. These oversimplifications are drivel. Also, how can something be "anti catabolic" (catabolism is the breakdown of complex biologic compounds into simpler compounds) at the same time that they increase "fat burning" and reduce "body fat deposition (which would be anti-anabolic)?
richw:
Do you have a link or brand name to give us a clue what you are asking about?
-Robert
Here in the U.S. you can buy what is essentially pharmaceutical grade fish oil at Costco. Stuff is dirt cheap. I take 5-8 capsules a day.
-k-
Really? WOW! I was taking two a day and had to lower my dose to 1 pill every other day. My blood pressure is often something like 94/55 on just two a day! They are a blood thinner, plus I have low iron problems (supposedly solved with iron supps), but I don't know how anyone takes that amount.
Which just proves we are all an experiment of one.
-Robert
i don't understand how on the capsule boxes it says "max 2 a day", but on the liquid oil boxes it says "max 2 teaspoons a day". a teaspoon is a much bigger dose than a capsule.
The exact mechanism in which fish oil potentates fat loss isn't completely understood. There seems to be both exercise and non-exercise pathways. Here are some potential ways that fish oil can help boost fat burning:
• DHA has been shown to prevent the conversion of pre-adipocytes to adipocytes and mediate pre-adipocyte death (kill 'em before they become immortal fat cells). (1)
• Fish oil has the ability to increase the clearance of chylomicrons and fats following a meal. This potentially can have a positive effect on substrate utilization. (2)
• Fish oil can "artificially" decrease heart rate thus increasing the level of exertion needed to reach desired intensity.
• Fish oil upregulates mitochondrial machinery and increases oxidation of fats within fat cells. (3,4)
References:
1. Kim HK, Della-Fera M, Lin J, Baile CA. Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes. The Journal of nutrition2006; 136: 2965-2969.
2. Smith BK, Sun GY, Donahue OM, Thomas TR. Exercise plus n-3 fatty acids: additive effect on postprandial lipemia. Metabolism 2004; 53: 1365-1371.
3. Flachs P, Horakova O, Brauner P, Rossmeisl M, Pecina P, Franssen-van Hal N, et al. Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia 2005; 48: 2365-2375.
4. Guo W, Xie W, Lei T, Hamilton JA. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids 2005; 40: 815-821.
wait a minute, there are immortal fat cells?Is there anything that can be done to kill them?
Lipo suction can remove some fat cells I guess. I belive Ano was refering to the fact that once fat cells are created they are very resistant, and don't Disapear they get smaller. That's one of the reasons people that were never fat gain weight much slower and formally fat people have to always be on vigile. Darn evolution, There's no way I'm gonna starv let the fat go
wow, that's amazing, I had no idea.Is there no way of killing them though?
Yeah, this is more esoteric Lyle McDonald-ish stuff.
But basically the theory goes that to *really* detoxify your body, you have to lean out. And then, at that point, you have to eat an abdundance of healthy fat, specifically polyunsaturates with a very favorable O3:O6 ratio in order to kinda realign your hormonal profile. If you can get the body to store the polyunsaturated as bodyfat, then you can really get this to work. That in turn will kick off a kind of anti-aging effect in your body.
Do you mean a slow down in aging or a reverse?
Lipo suction can remove some fat cells I guess. I belive Ano was refering to the fact that once fat cells are created they are very resistant, and don't Disapear they get smaller. That's one of the reasons people that were never fat gain weight much slower and formally fat people have to always be on vigile. Darn evolution, There's no way I'm gonna starv let the fat go