Delpo was the first to beat both #1 Fed and #2 Rafa in a GS. Stan is the first to beat both #1 Rafa and #2 Djoker in a GS. Not sure if anybody beat #1 Djoker and #2 Rafa as well.
Stan's also the lowest seeded winner of any Major since the 2004 French Open, when Gaudio won it unseeded (ranked 44 in the world going into the tournament).